The Spectrin-Ankyrin Skeleton Controls CD45 Surface Display and Interleukin-2 Production
نویسندگان
چکیده
منابع مشابه
Dynamic regulation of CD45 lateral mobility by the spectrin-ankyrin cytoskeleton of T cells.
The leukocyte common antigen, CD45, is a critical immune regulator whose activity is modulated by cytoskeletal interactions. Components of the spectrin-ankyrin cytoskeleton have been implicated in the trafficking and signaling of CD45. We have examined the lateral mobility of CD45 in resting and activated T lymphocytes using single-particle tracking and found that the receptor has decreased mob...
متن کاملPosttranslational control of membrane-skeleton (ankyrin and alpha beta- spectrin) assembly in early myogenesis
Adult chicken skeletal muscle cells express polypeptides that are antigenically related to alpha-spectrin (Mr 240,000) and beta-spectrin (Mr 220,000-225,000), the major components of the erythrocyte membrane-skeleton, and to ankyrin (Mr 237,000; also termed goblin in chicken erythrocytes), which binds spectrin to the transmembrane anion transporter in erythrocytes. Comparative immunoblotting of...
متن کاملPosttranslational Control of Membrane-Skeleton (Ankyrin and c /3-Spectrin) Assembly in Early Myogenesis
Adult chicken skeletal muscle cells express polypeptides that are antigenically related to ce-spectrin (Mr 240,000) and/3-spectrin (Mr 220,000-225,000), the major components of the erythrocyte membrane-skeleton, and to ankyrin (Mr 237,000; also termed goblin in chicken erythrocytes), which binds spectrin to the transmembrane anion transporter in erythrocytes. Comparative immunoblotting of SDS-s...
متن کاملWhere spectrin snuggles with ankyrin.
individual Plg-Rs to monocyte recruitment may change over time (enolase-1 early vs H2B later). These suggestions imply that different populations of Plg-Rs could be targeted to regulate inflammatory cell recruitment in a temporal or site-specific manner. The resurrection of enolase-1 as a Plg-R by the Wygrecka et al provides impetus for such comparative studies. Conflict-of-interest disclosure:...
متن کاملThe axonal membrane cytoskeletal protein A60 and the development of the spectrin/ankyrin-based neuronal membrane skeleton.
Introduction Among the processes of developing a polarized neuron from an undifferentiated neuronal precursor is the extension of neurites and their differentiation into dendrites and axons. The formation of synaptic contacts, myelin sheaths and nodes of Ranvier lends complexity to the surface of neurons. To generate such diversity and specialization of membrane domains a complex series of even...
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ژورنال
عنوان ژورنال: Immunity
سال: 2002
ISSN: 1074-7613
DOI: 10.1016/s1074-7613(02)00396-5